Fermentation Expertise

Innovating Fermentation Processes for Seamless Development and Manufacturing

Curia’s dedicated fermentation teams combines state-of-the-art facilities with expert knowledge to deliver customized solutions, from development to manufacturing. Our track record showcases unparalleled quality and regulatory compliance. With a multidisciplinary approach and versatile feedback control systems, we are adept at tackling challenges from benchtop experiments to full-scale production.

  • Microbial Strain Improvement: Conducted in cutting-edge labs with precision fermentation techniques, Curia is able to work with bacteria, yeast and fungi (both engineered and natural strains
  • Process Optimization: Scale-up capabilities for preclinical, clinical trials or manufacturing
  • Proven Success: A variety of case studies highlight Curia’s ability to rapidly deliver robust, cost-advantaged processes, new intellectual property (IP), and novel natural products (microbial collection)

Flexible Scale, Customization and Downstream Capabilities

With over 20 years of experience, Curia excels in manufacturing, isolating and purifying complex biological mixtures. Our infrastructure includes reactors ranging from 2L to 7,000L with advanced monitoring tools and broad DSP capabilities.

Key Capabilities Include:

Industrial Fermentation and Biotransformation

Curia excels in:

  • Seamlessly integrating biocatalysis with advanced chemical synthesis
  • Creating innovative and efficient processes that optimize both safety and scalability
  • Multidisciplinary approaches to unlock new intellectual property opportunities
  • Downstream process excellence, including scale-up capabilities for large volumes with solvent-optimized processes

Your Product, Our Expertise

Curia Network

Fermenters
5 – 15,000 L

Reactors
2 – 7,000 L

Chromatography Columns
2 – 500 L

Expertise and Capabilities

  • Fermentation from early development to scale-up
  • Centrifugation and filtration
  • Tangential flow filtration, including MF, UF, NF and DF
  • Liquid-to-liquid extraction
  • Industrial chromatography
  • Chemical synthesis
  • Analytical services

Quality and Regulatory

  • Phase-appropriate GMP
  • Experience supporting filings worldwide

Fermenters
30 – 48,000 L

Reactors
15 – 6,200 L

Chromatography Columns
2 – 500 L

Expertise and Capabilities

  • Fermentation services from scale-up to manufacturing
  • Industrial chromatography
  • Scale up from development to commercial manufacturing
  • Tangential flow filtration, including MF, UF, NF and DF
  • Press filter
  • Analytical services

Quality and Regulatory

  • FDA, AIFA, PMDA and ANVISA
  • Experience supporting regulatory filings across the globe

Fermentation Frequently Asked Questions