Integrated biologics services

End-to-end solutions for therapeutic and diagnostic biomolecules

Curia offers integrated expertise in the production and evaluation of antibodies, DNA, viral vectors, mRNA, cell lines, proteins, and conjugates.

Center of Excellence for biologics

Antibody Discovery & Engineering

Delivery of your next panel of therapeutic leads

Curia offers a comprehensive array of antibody discovery and engineering services to identify, optimize, and characterize new leads. Whether you need an IgG, scFv, Fab, VHH, or multiple formats, our experienced technical teams partner with you to help deliver the right molecules that demonstrate the function, selectivity, and cross-reactivity you need. Optimal, high-quality and accelerated antibody discovery workflows are available in the following technology platforms: hybridoma, single B cell with the Beacon system, phage display, and yeast display. Curia’s integrated services include immunizations, panning and screening, cloning, NGS and Sanger sequencing, sequence diversity and therapeutic developability analysis, humanization, and affinity maturation. Downstream high-throughput transient and stable antibody production, process development, and GMP manufacturing services are also streamlined and offered.

Antibody & Protein Production

Extensive experience with Ab and protein production in multiple platform

Curia offers production of recombinant proteins and antibodies via transient CHO and other expression platforms. TunaCHO™, a proprietary technology platform for CHO transient production, delivers highest production yield compared to other commercial cell lines. At Curia, we apply unparalleled analytical capability to all recombinant antibodies to enhance quality and peace of mind. Curia also offers a wide range of protein engineering services including molecular design, construction and gene synthesis in mammalian, microbial and baculoviral systems. All expression, purification and characterization are performed at our US-based facilities.


Highly efficient, fully integrated development programs

Our CHO-GSN™ platform is a CHO stable cell line development service using its proprietary cell line, custom stable expression vectors, and glutamine synthetase (GS) selection technology platform for the generation of a research cell bank (RCB) and future use as a manufacturing cell line for commercial products. Curia provides upstream process development (USP) services to optimize cell productivity in single-use bioreactors (SUB) and downstream process development (DSP) services for all protein-based technologies to engineer purification processes for manufacturing. Our technical team has developed purification schemes for hundreds of unique proteins for pre-clinical toxicology material.


Comprehensive cGMP manufacturing services

Our integrated biologics services include GMP manufacturing. Curia’s Hopkinton, Mass., facility is ISO 13485:2016 certified and provides biomanufacturing services for GMP and BPG production of plasmid DNA, mRNA, protein therapeutics and vaccines, and therapeutic antibodies. Hopkinton offers an established quality system to support production of early phase bulk drug and diagnostic products. Our systems are compliant to applicable portions of 21CFR Parts 210, 211, 600, 610, and 820. We also offer a full service cGxP Analytical and QC workflow meeting USP, Ph. EU., and FDA guidelines with a full menu of analytical, bioassay, and microbiology services.

Assays & Bioanalytics

Broad selection and flexibility in capacity, assay design, execution

Curia provides a wide range of molecular, biochemical and cell-based bioassay workflows to support discovery, research & development as well as cGxP therapeutic testing campaigns across all service types. Our integrated service platforms provide full access to Curia expertise across all of our sites and smooth transitions from R&D to cGxP workstreams.

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