Curia – León & San Cristóbal, Spain

Fermentation production and downstream processing, from cell bank to 15,000 L scale.

Curia’s León and San Cristóbal facilities in Spain specialize in biotechnology development services, fermentation production and downstream processing for the pharmaceutical, cosmetic and food industries. Together, the two sites offer fermentation from 5 L to 15,000 L, aqueous and organic solvent processing on ATEX-certified equipment, tangential flow filtration, liquid-liquid extraction and industrial chromatography.

Facilities at a glance

Expertise

50+ experts

A biotechnology team spanning strain development, fermentation, downstream processing and chemical synthesis across León and San Cristóbal.

Fermentation

5 L to 15,000 L

Supporting 1 mL long to 10 mL syringes with speeds up to 8,000 units/hour Card 3

Reactor range

2 L to 7,000 L

Reactors from 2 L to 7,000 L support bioconversions, extraction and chemical synthesis steps.

Chromatography

Columns from 2 L to 500 L

Industrial chromatography columns purify products from development through scale-up.

Quality

Best-practice quality metrics

Operations run under best-practice quality metrics with centrifuges, filters and dryers at scale.

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León & San Cristóbal site capabilities overview

What these sites do

From cell banks to large-scale fermentation

Fermentation services span cell banks, GMO strains, strain improvement, fermentation development, fermentation scale-up and bioconversions, carrying programs from early development into production.

Aqueous and organic solvent processing at scale

León and San Cristóbal offer clarification and separation: aqueous filtrations and centrifugations of fermentation broth, and organic solvent processing on ATEX-certified decanter and tricanter equipment.

TFF from lab to large scale

Tangential flow filtration equipment for microfiltration, ultrafiltration, nanofiltration and diafiltration supports lab, pilot and large-scale operations.

ATEX-certified extraction and phase separation

ATEX-certified equipment supports liquid extraction, phase separation and thermal processing, giving solvent-based downstream steps a safe, compliant home within the same two-site operation.

Purification from development to scale-up

Expertise in normal phase, reverse phase and ion exchange chromatography supports purification from development to scale-up, including lipids for lipid nanoparticles, nucleotides and proteins.

Synthesis steps alongside biotechnology

Typical chemical syntheses, including protections, cyanation, decarboxylation and hydrolysis, can be performed to complement fermentation and downstream processing.

Why clients love this site

Strain to scale with one partner

Cell banking, strain improvement and fermentation development flow directly into scale-up and production fermentation.

Complete downstream processing

Aqueous and organic solvent processing, TFF, liquid-liquid extraction and industrial chromatography take products from broth to purified output across two sites working as one.

Beyond pharma

León and San Cristóbal serve pharmaceutical, cosmetic and food industry programs.

Europe’s fermentation anchor

León and San Cristóbal anchor Curia’s European fermentation footprint, a recognized strength of the network.

How these sites fit into Curia’s network

Rozzano Quinto, Italy – GMP fermentation and chromatography

Rozzano Quinto adds GMP fermentation and industrial chromatography to Curia’s Italian footprint, with a multipurpose pilot plant for scale-up from 1 to 60 kg.

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