Origgio, Italy

Curia – Origgio, Italy

API and intermediate manufacturing through chemical synthesis, with hydrogenation to 14 m³.

Curia’s Origgio facility develops and manufactures active pharmaceutical substances and intermediates through chemical synthesis. The site pairs 549 m³ of synthesis capacity and reactors up to 16,000 L with specialist depth in hydrogenation, boronic acid chemistry, lithiation and carbonylation, under FDA, AIFA and PMDA inspection.

Facility at a glance

Expertise

240+ experts

A deep technical and operations team for complex chemical synthesis at commercial scale.

Reactor range

100 L to 16,000 L

A broad reactor fleet spans development batches through large commercial campaigns.

Synthesis capacity

549 m³

549 m³ of chemical synthesis capacity across the site.

Hydrogenation

0.8 to 14 m³

Six hydrogenators up to 14 m³ handle complex API steps with high yield.

Compliance

FDA, AIFA and PMDA inspected

Multi-agency inspection history supports worldwide commercial supply.

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Origgio site capabilities overview

What this site does

Six hydrogenators, up to 14 m³

Origgio is experienced in complex API hydrogenation steps with high yield, handling metal catalysts including palladium, rhodium and platinum across six hydrogenators up to 14 m³.

Pd-catalyzed cross-coupling under GMP

The site specializes in palladium-catalyzed cross-coupling with organoboron compounds for high-purity pharmaceutical intermediates, with expertise in organometallic reagents and transition metal catalysts under strict GMP.

450+ cryogenic reactions every year

Origgio runs more than 450 cryogenic reactions yearly, including lithiation and organometallic steps for precise boronic acid derivative synthesis.

Reactive chemistry under precise control

Specialized capability in complex carbonylation and phosphorylation reactions requiring precise control of high temperatures and reactive intermediates.

On-site ecological waste treatment

An ecological unit area for waste treatment supports responsible large-scale chemical operations on site.

Why clients love this site

Specialist chemistry at commercial scale

Hydrogenation, boronic acid cross-coupling, lithiation and carbonylation expertise applied to complex APIs and intermediates.

Cryogenic throughput, year after year

More than 450 cryogenic reactions run annually, including precise lithiation and organometallic steps.

Globally inspected quality

FDA, AIFA and PMDA inspection history supports supply into major regulated markets.

Capacity to grow with your program

549 m³ of synthesis capacity and reactors to 16,000 L take programs from development to full commercial volume.

How this site fits into Curia’s network

Rozzano Quinto, Italy – Fermentation and chromatography

Rozzano Quinto adds GMP fermentation and industrial chromatography to Curia’s Italian footprint, with a multipurpose pilot plant for scale-up from 1 to 60 kg.

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