Frankfurt, Germany

Curia – Frankfurt, Germany

Quick scale-up and manufacturing of complex small molecules, regulatory starting materials and unique fine chemicals.

Curia’s Frankfurt facility specializes in the rapid scale-up and manufacture of complex small molecules, particularly regulatory starting materials and unique fine chemicals. The site combines 48 m³ of total reactor volume with specialist capabilities in phosphonic acids, hydrogenation, enzymatic chemistry and high-performance distillation.

Facility at a glance

Expertise

70+ experts

An experienced team focused on complex chemistry, scale-up and fine chemicals production.

Total capacity

48 m³ reactor volume

48 m³ of total reactor volume support scale-up and manufacturing campaigns.

Reactor range

50 L to 3,000 L

Reactor capacity from 50 to 3,000 L carries chemistry from lab through production.

Pilot plant

100 kg to >1,000 kg

Pilot plant output spans 100 kg to more than 1,000 kg.

Quality

DIN ISO 9001:2015 certified

Certified quality management underpins fine chemicals and starting material supply.

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Frankfurt site capabilities overview

What this site does

Home of T3P®, Curia’s patented coupling reagent

Frankfurt manufactures phosphonic acid products including T3P, Curia’s patented reagent for efficient coupling, and VPA, a chromium-free solution for corrosion protection.

Hydrogenation from lab to cubic-meter scale

Hydrogenation equipment spans 300 mL to 1 L at lab scale and up to 1 m³ in the pilot plant, with both glass-lined and stainless-steel vessels available.

Chiral technologies and biocatalysis

Chiral technologies such as enantioselective hydrogenation combine with enzyme capabilities including lipases, ADHs/KREDs and transaminases to deliver selective, efficient routes to complex targets.

Distillation up to 100 theoretical plates

Distillation columns up to 2.5 m³ with up to 100 theoretical plates, vacuum down to 2 mbar, and the ability to distill low-melting solids give Frankfurt purification capabilities that few sites can match.

From 50 L to production campaigns

With reactors from 50 to 3,000 L, a pilot plant delivering 100 kg to more than 1,000 kg, and 48 m³ of total volume, Frankfurt scales complex small molecules, regulatory starting materials and specialty fine chemicals quickly.

Why clients love this site

Proprietary reagent chemistry

T3P, Curia’s patented coupling reagent, is manufactured here, alongside chromium-free VPA for corrosion protection.

Speed from lab to plant

Quick scale-up is the site’s specialty, moving complex chemistry from 50 L reactors to 1,000+ kg pilot plant campaigns.

Purification that solves hard problems

High-performance distillation with up to 100 theoretical plates, 2 mbar vacuum and low-melting-solid capability.

Selective, sustainable routes

Enzymatic chemistry and enantioselective hydrogenation offer efficient chiral routes to complex intermediates.

How this site fits into Curia’s network

Origgio, Italy – API manufacture with hydrogenation depth

Origgio carries hydrogenation to 14 m³ scale and manufactures APIs and intermediates under GMP, a natural downstream partner for Frankfurt’s starting materials.

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Rensselaer, NY – US commercial API manufacture

Rensselaer manufactures highly potent and controlled APIs at commercial scale in the US, supplied by regulatory starting materials from sites like Frankfurt.

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