Selective 2,3’-Homodimerization of Indoles Using Mechanochemistry: A Convenient Synthesis of 2,3’-Biindoles
Authored by Dr. Satyanarayana Tummanapalli, Small Molecule Development, Curia
This article, recently published in ChemistrySelect, presents a sustainable and efficient approach to synthesizing 2,3’-biindoles—key structural motifs in many biologically active natural and synthetic compounds.
The research outlines a Pd-catalyzed 2,3′-homodimerization of indolyl groups using a Liquid-Assisted Grinding (LAG) mechanochemical process. This method eliminates the need for solvents and oxidants, offering a greener, atom-economical alternative that minimizes hazardous waste, shortens reaction times, and enhances overall efficiency.
Mechanochemistry continues to gain relevance as a practical and environmentally conscious technique in modern organic synthesis.