Poster: Accelerating Discovery Success with Structure-Guided Drug Design: A worked example from a challenging DNA-repair target, Artemis
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Download this poster to discover how our team of experts were able to produce the first crystal structure of a challenging but promising target, Artemis. The analysis of the 3D structure, in combination with high throughput screening, identified a novel binding site. Co-crystals of new medicinal chemistry analogs allowed a rapid improvement of the inhibition to low nM IC50’s. The Curia team of structural biologists, medicinal and computational chemistry was able to improve potency ~500 fold while creating novel chemical matter.
