Adeno Associated Virus (AAV)
The Vector Technology group utilizes the mammalian and baculovirus platforms for the production of AAV, with a focus on vector engineering and optimization, process development, and scale-up production. The technical team at Curia has over 16 years of experience utilizing suspension insect cell lines and the baculovirus system for the production of recombinant proteins and the AAV platform expands on those capabilities. Extensive characterization capabilities are also available with our assay group.
Key Features of AAV Production Platform
| Mammalian | Baculovirus |
|---|---|
| – HEK293 production platform – Suspension and adherent options – Helper-free system – Up to 100L culture production | – Suspension-based culture (Sf9) – High titer baculovirus production within 2 weeks – BIIC research cell banks – Up to 100L culture production |
Vector Services for Advanced Therapies
Explore our vector services that include process development, FTE programs and project management.
Case Study
Purity and identity characterization of AAV capsid particles by LC-MS methods.