DNA Services for mRNA Programs
Curia is aware of the evolving landscape of regulatory requirements and has addressed the landscape by offering a variety of DNA services to fit the needs of your program. We know the quality of the final product is only as good as the starting blueprint and we’ve developed methods and testing to ensure the quality designed in the most difficult to manufacture templates.
Offerings
Bioprocessing Grade DNA
- Derived from vetted E.Coli strains for phase appropriate programs
- In-house plasmid design and construction in a dedicated workspace
- Production from microgram to gram level as scaled to client and program needs
- Batch testing and release assays to meet regulatory filing requirements
- Testing and confirmation of transcribed mRNA products for each activity
Research and GMP quality synthetically made DNA
- Curia has partnered with Touchlight to offer advanced technology in enzymatic doggybone DNA (dbDNA™)
- No Bacterial source, no antibiotic testing for release and polyA tail retention
- Enzymatically quick and simplified purifications (5 day manufacturing)
- dbDNA™ backbone is compact (78% the size of this comparable E.coli) for difficult large inserts