DNA Services for mRNA Programs
Curia is aware of the evolving landscape of regulatory requirements and offers a variety of DNA services to fit the needs of your program. We know the quality of the final product is only as good as the starting blueprint. We’ve developed methods and testing to ensure the design of your template meets your stringent manufacturing needs.
Offerings
Bioprocessing Grade DNA
- Derived from vetted E.Coli strains for phase appropriate programs
- In-house plasmid design and construction in a dedicated workspace
- Production from microgram to gram level, scaled to client and program needs
- Batch testing and release assays to meet regulatory filing requirements
Research and GMP grade synthetic DNA
- Curia has partnered with Touchlight to offer advanced technology in enzymatic doggybone DNA (dbDNA™)
- No Bacterial source, no antibiotic testing for release and polyA tail retention
- Enzymatic process is quick, with simplified purifications
- dbDNA™ backbone is compact (78% compared to E.coli)