Downstream Process Development
Curia provides downstream process development (DSP) services which maximize purity and recovery across an array of molecules.
Our technical team has developed purification schemes for hundreds of unique proteins for pre-clinical tox material. Our platform processes are designed to maximize purity and yield, while minimizing the time between development and toxicology studies. The developed processes are tailored to meet our client’s specifications.
Curia Offers Two Standard DSP Platforms
- Antibody/Fc fusion proteins/bi/tri-specifics.
- Proteins (cytokines, growth factors, anticoagulants, vaccines, enzymes).
Services Include
- Chromatography capabilities include all modalities (affinity, IEX, HIC, RP, MMC)
- Virus inactivation (pH and detergent)
- Ultrafiltration and Diafiltration
- All processes validated for scalability for manufacturing
- Services can be performed in parallel with upstream and analytical development services to reduce the time between development and toxicology studies
We also support client collaboration on your needs for:
- Direct communication and a partnership with our technical team
- Weekly updates and study reports detailing your program’s advancement
