Cell Line Development
Curia offers advanced methods to rapidly move programs from DNA to RCB in weeks utilizing methods to ensure clonality and maximize titer across CHO, HEK 293, and other mammalian cell lines.
Mammalian cell line development needs innovative technologies to ensure the cell line offers ensured clonality to maximize yields while delivering the necessary quality guarantees.
Our Technological Approach
- Electroporation to ensure efficient delivery of desired genes of interest to the cellular fabric
- Single cell plating to isolate multiple high expressors
- Cellular imaging to monitor proliferation of a consistent monoclonal cell line
Features
- Stable transfections to CHO-GSN℠ and CHOZN® cell lines
- Proven stability >60 generations
- Single cell cloning and monitoring for production of stable research cell lines
- Documented progression of research to master cell bank implementation