Solid State Chemistry
Physical properties of a molecular entity can vary greatly depending on the solid form (salt, cocrystal, amorphous dispersion or crystalline polymorph). By screening and selecting solid forms early in development, we provide the basis for consistent production and performance while reducing costs associated with toxicological bridging studies or further process development efforts. Optimization of available solid forms provides an opportunity to overcome physical property challenges or potential form control issues by identifying more promising alternatives.
We provide a complete suite of solid-form screening services to select the most appropriate solid forms for intermediates and drug substances. Sensitive to the different requirements of drug indication, stage of development, intended formulation and storage conditions, our experts customize investigations to identify the most appropriate forms for desired physical properties and controlled scale-up.
Solid Form Services:
- Solid form screening and candidate selection
- Polymorphs, hydrates, and solvates screens
- Multi-component crystalline forms: salts, cocrystals, chiral resolution, complexation screens
- Fit-for purpose screening: stable form, hydrate, enabling form screen, IP screens
- Crystallization screens for hard-to-crystallize materials
- Amorphous solid dispersion screens
- Single crystal growth and crystal structure determination
- Comprehensive physical properties investigation
- Establishing thermodynamic and kinetic relationships
- IP protection strategies for drug substance
- Computational analyses
- Software – indexing, pattern matching, and structure from XRPD
- Crystallization process development including optimization and troubleshooting
Instrumentation:
- TRIADS™ algorithm platform for indexing
- High-resolution X-ray powder diffraction (XRPD) with variable temperature and humidity
- Single crystal X-ray diffraction (SC-XRD)
- Intrinsic dissolution
- Solubility determination
- Dynamic vapor sorption
- Spray/Freeze dryer
- Lyophilization
- Crystal16
- Easymax
- Lara controlled lab reactor