Scaling Organometallic Chemistry with Confidence

Curia supports organometallic chemistry from reagent preparation and process development through commercial manufacturing. Its six-site network combines cryogenic processing, organometallic reagent handling and carbon-carbon and carbon-nitrogen bond-forming chemistry. For teams evaluating a route to scale, this fact sheet identifies the reaction capabilities, reactor sizes and locations relevant to process and manufacturing planning.

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Organometallic capabilities at a glance

• Cryogenic processing at industrial scale. The network includes reactors operating at temperatures as low as −100 °C, with reactor volumes up to 10 m³ at Springfield. Available scale and processing conditions depend on the selected site.
• Reagent preparation and bond formation. Capabilities cover Grignard and organolithium chemistry, with organoboron reagents available through off-the-shelf supply or custom manufacture. Cross-coupling expertise includes Suzuki, Kumada, Negishi and Buchwald-Hartwig reactions.
• Site selection matched to the process. The resource maps capabilities across Springfield, Rensselaer, Frankfurt, Bon-Encontre, Origgio and Hyderabad. It distinguishes Frankfurt’s non-GMP development and scale-up offering and Hyderabad’s laboratory and pilot flow-reactor capabilities.

Use the full two-page fact sheet to compare site-specific reactor capacities and chemistry capabilities, and identify the right starting point for a discussion about your process.

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