Industrial Chromatography

Curia provides industrial-scale chromatographic purification for lipids, antibiotics, nucleotides and complex active pharmaceutical ingredients (APIs). Column capacity runs from 100 mL for process optimization to 500 L for large-scale production, with ATEX-compliant facilities in León and San Cristóbal, Spain, and Rozzano, Italy. For teams planning a purification step that has to scale, this fact sheet sets out the column ranges, separation modes and connected processing capabilities relevant to development and manufacturing decisions.

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Chromatography capabilities at a glance

• Three defined column scales. Development columns from 100 mL to 4 L support process optimization. Pilot columns from 16 L to 30 L support scale-up validation, and manufacturing columns from 70 L to 500 L support large-scale production. Both steel and glass columns are available.
• Separation modes matched to the molecule. The fact sheet lists normal-phase, reverse-phase, ion-exchange, affinity and size-exclusion chromatography, supported by more than 30 years of chromatography experience. The appropriate mode depends on the product’s chemistry and the impurities that must be removed.
• Solvent handling and connected processing. ATEX compliance supports safe processing of volatile compounds. At the Spanish and Italian sites, chromatography operates alongside fermentation and downstream processing, so purification can be planned together with upstream production and product recovery.

Download Industrial Chromatography at Scale for the column range at each stage, the supported separation modes and the European sites where chromatography connects with fermentation and downstream processing. Use it to frame a discussion about purification development, scale-up and the equipment needed for commercial supply.

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