Therapeutic Developability Analysis

Evaluating the developability of therapeutic drug candidates early can help circumvent potential issues in late-stage development. These evaluations include the drug candidate’s biophysical and chemical properties assessment. At Curia, in silico predictive tools and a series of fast & small-scale assessments are employed to serve as additional selection criteria for better and safe therapeutic leads.

Curia offers three developability assessment packages:
Developability Package 1 Developability Package 2 Developability Package 3
– In silico sequence liability analysis
– In silico immunogenicity analysis
– Turnaround time: 1 week
– Polyspecificity assessment
– Integrity and stability assessment
– Turnaround time: 2-3 weeks
– Buffer exchange
– Forced degradation
– Integrity and stability assessment
– Additional stress conditions
Key Highlights

In silico Analysis: Application of Bioinformatic Tools

  • Heavy and light chain variable region liability analysis
  • VH and VL analysis with identification of core residues with potential affinity to MHC class II

Rapid Integrity Assessments and Formulation Studies for Drug Candidates

  • Polyspecificity and integrity assessment can be completed in 2-3 weeks
  • Formulation studies can be completed in 5 – 6 weeks, including the standard 2 weeks of incubation for accelerated stress conditions

Robust Bioanalytical Assays and Formulation Studies with Minimal Materials Required

  • The standard panel includes common formulations used for commercial antibodies
  • Various bioanalytical assays and characterization tools are provided
  • A small amount of materials are needed for the bioanalytical assays and formulation studies.
Catalog # Name Timeline Price
1000 Developability Package 1 1 week Request
2000 Developability Package 2 3 weeks Request
3000 Developability Package 3 6 weeks Request

 

Antibody Discovery & Engineering Services

The Curia Antibody Center offers comprehensive antibody discovery and engineering services, including identification, optimization, and characterization of new leads.

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Developability Assessment Services

Curia’s dedicated facility in Hayward for upstream and downstream process development, research cell bank (RCB) generation, and GMP manufacturing of analyte specific reagents.

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