Curia performs a wide variety of biochemical assays to support drug discovery efforts in both the small and large molecule arenas. Our Assay team has a broad experience base traditional enzyme kinetic analyses and ligand-binding assays as well as cutting edge kinetic analysis utilizing Octet Biolayer Interferometry (BLI) utilizing a wide variety of readouts and technologies. The assay team leverages the full menu of Multimode Readers, Genetic Assay Technologies, and Analytical Instruments available across Curia. A variety of liquid handling technologies and platforms are available to support studies at a small scale as well as at full HTS scale.

Assay Type Highlights:
  • Enzyme Activity and Kinetic Evaluation
  • Binding Affinity Determinations
  • Immunoassays
  • Membrane Prep Ligand-binding Assays
  • HTS/Structure activity relation (SAR) screening and Secondary screen potency determinations
  • Full customization of workflow and assay formats available
Assay Format/Technology Highlights:
  • Fluorescent/Luminescence: HTRF, FP, FRET, AlphaLISA, AlphaScreen, Glo, Luciferase
  • ELISA-Based: Meso Scale Discovery ECL and traditional TMB
  • Spectrophotometric Abs and Radiometric Readouts
  • HPLC and LC/MS methodologies
  • Full Custom Development; Discovery through cGxP Assay Support
Liquid Handling Highlights:
  • Formulatrix Tempest Automated Dispenser Platform
  • 96/384 Channel Pipettors from Integra Biosciences and Apricot Technologies
  • Tecan d300e Digital Dispenser
  • Labcyte Echo 550 (3rd Party Collaboration)


Catalog # Name Timeline Price
1057 Customized Biochemical Assays TBD Request