Small Molecule Compound and Natural Product Libraries

Curia has created a series of unique, high-purity, cost-effective, small molecule synthetic compound libraries designed for screening and hit-to-lead programs.

We fully support identification and progression of actives from any of these libraries with high-throughput screening, lead optimization services, analytical and solid state services, custom synthesis and/or small- or large-scale manufacturing.

The CLC provides access to diverse, high-quality compounds. Our emphasis is on designing novel, core compounds and templates, exploring a new chemical space by first identifying a set of compounds and then synthesizing the right compounds, purifying them to greater than 90 percent before delivery. Our objective is to achieve compounds with the best chance of providing you with quality leads suitable for optimization activities.

Read more in The Compound Library Consortium (CLC) white paper.

Curia’s Synthetic Compound Collection comprises 105,000 compounds divided into sub-libraries of fragment-like, lead-like and drug-like molecules as starting points for hit identification through high-throughput screening.

Curia possesses the diverse scientific expertise and advanced technology to establish compound libraries, conduct hit-to-lead screening and pursue a medicinal chemistry approach within a single organization.

Curia’s Collection is a large, diverse selection of small molecule organic compounds that are pre-plated in 384-well format. Our expert medicinal and computational chemists developed, tested and refined compound selection and elimination criteria to retain only viable chemical starting points for lead discovery. The Collection provides an opportunity to identify high-quality hits through high-throughput screening (HTS) suitable for medicinal chemistry exploration.

The collection holds 105,000 compounds divided into sub-libraries of fragment-like, lead-like and drug-like molecules. The diversity of scaffolds results in novel chemical starting points, and the entire collection and individual sub-libraries are available to accommodate your program needs. We have already analyzed the library based on scaffolds and cluster analysis, resulting in removal of potential false-negatives and false-positives and rapid development of structure-activity relationships.

Key elements include:
  • 4,748 fragment-like compounds prepared with a larger quantity of material per well to support low-volume, high-concentration test formats
  • 54,337 lead-like compounds. M.W. 250–400; LogP 0–5; rings ≤ 4
  • 46,237 drug-like compounds. M.W. 400–500; LogP 4–~ 5.5; rings ≤ 5
  • Resupply of compounds from dry powder inventory, commercial sources or resynthesis by Curia chemists

We accomplish hit triage quickly by purchasing related analogs and using other computational methods to perform virtual screening to identify additional compounds for testing.

We have collated a collection of nearly 300,000 samples derived from marine and terrestrial microorganisms and plants as a rich source of potential new chemical entities .

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