Stability in Plasma
- Blood plasma from desired species.
- Stability determined by measuring percent remaining of test compound at multiple time points during incubation in plasma.
|Test Compound Concentration
|Percent Organic Solvent in Incubation
||0, 15, 30, 60, and 90 minutes
||Propantheline and/or Enalapril
||LC-MS (LC-MS/MS if necessary)
|Number of Repeats
Deliverable: Half-life of test compound.
Test Compound Requirement: 1-2 mg dry powder or 100-200 µL of 10 mM DMSO stock solution.