Single Cytotoxicity Assay

Use of a mammalian liver cell line (HepG2) or normal human dermal fibroblasts (NHDF) to determine in vitro cytotoxicity and in vitro therapeutic index (when compared to MIC value(s)). Common method for identification and exclusion of overtly toxic compounds. Standard cytotoxicity detection methods employ MTT or Celltiter-Glo based detection.