Research and Development/ Discovery/ Curia Express/ In Vitro DMPK
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Services designed to facilitate your science.

Choose from the following in vitro DMPK and bioanalytical/pharmacokinetics services for the pharmaceutical, biopharmaceutical, and agrochemical industries.

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CYP Inhibition

CYP Inhibition, LC-MS/MS Detection (IC50 Determination)
Time Dependent Inhibition, LC-MS/MS Detection (IC50 Shift)
Time Dependent Inhibition, LC-MS/MS Detection (Ki/Kinact Determination)

CYP Reaction Phenotyping

CYP Phenotyping, Liver Microsomes
CYP Phenotyping, Recombinant CYP Isoforms
CYP Phenotyping, Recombinant CYP Isoforms, with Relative CYP Contribution

In Vitro Toxicity

Cytotoxicity in Hepatocyte Suspensions
Detection and Identification of Reactive Metabolites, Liver Microsomes
Detection and Identification of Reactive Metabolites, Liver S9 Fractions
hERG Cardiotoxicity
Mini-Ames Genotoxicity

Metabolic Stability

Metabolic Clearance, Liver Microsomes
Metabolic Clearance, Liver S9 Fractions
Metabolic Clearance, Mammalian Hepatocytes
Metabolic Stability, Liver Microsomes (Single Time Point)
Stability in Blood
Stability in Plasma

Metabolite Profiling and Identification

Express MP&I in In Vitro Clearance Samples - Hepatocytes
Express MP&I in In Vitro Clearance Samples – Liver Microsomes
Express MP&I in In Vitro Clearance Samples – Liver S9 Fractions
Metabolite Profiling and Identification in Mammalian Tissues or Fluids from In Vivo Studies
Standard In Vitro MP&I - Hepatocytes
Standard In Vitro MP&I - Liver Microsomes
Standard In Vitro MP&I - Liver S9 Fractions

Permeability

MDR1-MDCK Cells
PAMPA (Parallel Artificial Membrane Permeability Assay)
Permeability through Caco-2 Cells

Physicochemical Properties

Aqueous Solubility, Kinetic
Aqueous Solubility, Shake Flask
Chemical Stability
LogP/LogD

Additional Assays

Antibody-Drug Conjugate Analysis
Blood/Plasma Partitioning
CYP Induction in Cryopreserved Human Hepatocytes
Discovery Bioanalytical Services
N-Acetylation Using Human Recombinant N-Acetyltransferases or Liver Cytosol
Protein Binding, Equilibrium Dialysis - Brain Tissue
Protein Binding, Equilibrium Dialysis - Liver Microsomes
Protein Binding, Equilibrium Dialysis - Plasma
Synthesis of Metabolites
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